Detailed view for TVAG_010600

Basic information

TDR Targets ID: 905233
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 5.2225 | Length (AA): 188 | MW (Da): 22075 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06294   CH-like domain in sperm protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130310)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG16719   CG16719 gene product from transcript CG16719-RA
Drosophila melanogaster Dmel_CG12395   CG12395 gene product from transcript CG12395-RA
Echinococcus granulosus EgrG_000431600   sperm flagellar protein 1
Echinococcus multilocularis EmuJ_000431600   sperm flagellar protein 1
Giardia lamblia GL50803_12046   SPEF1-like protein
Homo sapiens ENSG00000101222   sperm flagellar 1
Leishmania braziliensis LbrM.20.1150   hypothetical protein, conserved
Leishmania donovani LdBPK_341200.1   Domain of Unknown Function (DUF1042), putative
Leishmania infantum LinJ.34.1200   hypothetical protein, conserved
Leishmania major LmjF.34.1120   hypothetical protein, conserved
Leishmania mexicana LmxM.33.1120   hypothetical protein, conserved
Mus musculus ENSMUSG00000027329   sperm flagellar 1
Plasmodium berghei PBANKA_0830300   conserved protein, unknown function
Plasmodium falciparum PF3D7_0929500   conserved protein, unknown function
Plasmodium knowlesi PKNH_0728000   conserved protein, unknown function
Plasmodium vivax PVX_099935   conserved protein, unknown function
Plasmodium yoelii PY05294   Homo sapiens dJ1009E24.4-related
Schistosoma japonicum Sjp_0062730   Sperm flagellar protein 1, putative
Schistosoma mansoni Smp_060160   hypothetical protein
Schmidtea mediterranea mk4.004422.02   Sperm flagellar protein 1
Schmidtea mediterranea mk4.006902.05  
Trypanosoma brucei gambiense Tbg972.4.3140   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.3130   Component of motile flagella 18
Trypanosoma cruzi TcCLB.506435.220   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506265.200   hypothetical protein, conserved
Toxoplasma gondii TGME49_256025   SPEF1 family protein
Trichomonas vaginalis TVAG_010600   conserved hypothetical protein
Trichomonas vaginalis TVAG_396500   Spermatogenesis-associated protein, putative
Trichomonas vaginalis TVAG_182680   conserved hypothetical protein
Trichomonas vaginalis TVAG_173660   conserved hypothetical protein

Essentiality

TVAG_010600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.3130 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.3130 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.3130 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.3130 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_256025 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_010600 (Trichomonas vaginalis), conserved hypothetical protein
Title for this comment
Comment